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Science · AU

Removing a genetic brake wakes silent genes in Prader-Willi syndrome, WEHI finds

Following since 2026-10-27 · last updated 2d

WEHI researchers at work
Researchers at WEHI, where scientists showed that removing the SMCHD1 protein can switch healthy genes back on in Prader-Willi syndrome.
  • Science

Removing a genetic brake wakes silent genes in Prader-Willi syndrome, WEHI finds

Mono Scoops 2d

Researchers at Melbourne's WEHI have shown that removing a protein called SMCHD1 lifts the genetic brake silencing healthy genes in Prader-Willi syndrome, restoring gene activity in patient-derived cells and animal models and opening a potential path to a treatment targeting the condition's cause.

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